Postdoctoral Fellow - Cancer Epigenetics and Therapeutic Target Discovery

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

Dr. David Chen's lab in Systems Biology is seeking a highly skilled and motivated Staff Scientist or Postdoctoral Fellow to join their dynamic team. Dr. Chen is a distinguished leader serving as the Director of the Division of Epigenetics and Transcriptional Engineering at City of Hope Cancer Center. His lab investigates epigenetic mechanisms of drug resistance and identifies therapeutic targets in various cancers through cutting-edge techniques such as high-throughput genetic screens (recent papers: PMID: 38316881, 38394203, 37075745, 36563143, 34373586, 34210975).

For more information about Dr. Chen’s lab, please visit here.

As a successful candidate, you will:

• Be involved in cancer genetics and epigenetics studies.
• Contribute to wet-lab (experimental) and/or dry-lab (computational) research.
• Utilize the cutting-edge CRISPR gene editing and screen approach to dissect cancer mechanisms.
• Combine multiomics tools (RNA-seq, ATAC-seq, ChIP-seq, single-cell sequencing, mass spectometry, etc.) and 3D protein structural analyses.
• Perform in vitro (cell culture) and in vivo (xenograft and PDX) cancer disease modeling.
• Participate in novel technology development, including CRISPR gene tiling, single-cell CRISPR screens, etc.
• Focus on cancer types including leukemia, lymphoma, GBM, breast cancer, HCC, Ewing sarcoma, etc.
• Collaborate with other researchers in the lab for multiple publications.